I've got several layouts and redesigns for mine on the backburner. I've stopped bothering to fret about them being unfinished and just accept that I'll do it when I do it.

I find my biggest block about it is trying to be TOO original. I'm sick to death of fixed-width centered stuff, so I want something variable-width like Cameron Adams or Jason Santa Maria. I'm sick of muted colours and monotones, so I want something bright like Dave Shea. I'm sick of the two-column #content+#sidebar, so I want a single column like Matt Mullenweg.

I think for me, the key will be to develop a layout that works as fixed and variable width-- fixed-single column for the homepage, two columns for nearly everywhere else, and a liquid column for photogallery.