One extremely efffective way to block ads without even using an ad blocker, is to block *every* domain owned by Facebook, using your hosts file (or at your router, if you have that luxury). The absolutely most intrusive ads come through their ad network. Once this is done, you will find the web much less obnoxious even if you have no adblocker installed.

This does, of course, have the side effect of disabling access to Facebook itself. I consider this a bonus feature, because no one should be on Facebook, ever. I'm certain that Rands will agree that Facebook is an open-ended time sink with no upside.