I deeply love Tweetdeck and is the only reason I still use Twitter. I make good use of the Lists feature and filter out a lot of nonsense. Like following gamers and removing every instance of "Twitch.tv" to get what they're saying, not when they go live.

It's so powerful and lovely. I live in fear of the day Twitter remembers they own Tweetdeck and try to ruin it in the same way they have the rest of the ecosystem.